Tag: FDCs

De facto combinations: Why taking separate generics instead of FDCs is common - and risky
Gina Lizet Feb, 3 2026

De facto combinations: Why taking separate generics instead of FDCs is common - and risky

Many patients take separate generic drugs instead of fixed-dose combinations (FDCs) for cost or dosing reasons. But this practice, called a de facto combination, carries hidden risks like lower adherence and untested drug interactions. Learn when it's safe - and when it's not.

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